The Mechanism of Action of Letrozole

Letrozole mode of action involves its role as an aromatase inhibitor. Aromatase is an enzyme responsible for the conversion of androgens into estrogens in the body. By blocking the activity of aromatase, letrozole reduces the production of estrogen, particularly in postmenopausal women where most of the estrogen is synthesized in peripheral tissues.

How Does Letrozole Work?

Letrozole acts by binding to the active site of the aromatase enzyme, thereby inhibiting its function. This prevents the conversion of androgens such as testosterone into estrogens like estradiol. By lowering estrogen levels, letrozole is used in the treatment of hormone receptor-positive breast cancer, as these types of cancer cells rely on estrogen for growth and proliferation.

Effects of Letrozole

By reducing estrogen levels, letrozole helps to slow down or stop the growth of hormone receptor-positive breast cancer cells. This can lead to tumor shrinkage and improved outcomes for patients undergoing treatment. Letrozole is often prescribed as an adjuvant therapy after surgery or as a first-line treatment for advanced or metastatic breast cancer.

In addition to its role in breast cancer treatment, letrozole is also sometimes used off-label for ovulation induction in women with infertility issues. By suppressing estrogen production, letrozole can help stimulate follicle development and increase the chances of successful ovulation and pregnancy.

Overall, the mode of action of letrozole as an aromatase inhibitor makes it an important medication in the management of hormone receptor-positive breast cancer and certain infertility conditions. Understanding how letrozole works can help healthcare providers and patients make informed decisions about its use in clinical practice.

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